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PortaJohn

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No worries - they already have an mRNA jab for Marburg! And the NIH already completed the first human clinical trials in January!!
BTW, this version of Marburg has a 90% mortality:

Marburg vaccine shows promising results in first-in-human study​


SEM image of rod-shaped Marburg virus particles, colorized blue.
Colorized scanning electron micrograph of Marburg virus particles (blue) both budding and attached to the surface of infected VERO E6 cells (orange).

What​

A newly published paper in The Lancet shows that an experimental vaccine against Marburg virus (MARV) was safe and induced an immune response in a small, first-in-human clinical trial. The vaccine, developed by researchers at the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health, could someday be an important tool to respond to Marburg virus outbreaks.

This first-in-human, Phase 1 study tested an experimental MARV vaccine candidate, known as cAd3-Marburg, which was developed at NIAID’s Vaccine Research Center (VRC). This vaccine uses a modified chimpanzee adenovirus called cAd3, which can no longer replicate or infect cells, and displays a glycoprotein found on the surface of MARV to induce immune responses against the virus. The cAd3 vaccine platform demonstrated a good safety profile in prior clinical trials when used in investigational Ebola virus and Sudan virus vaccines developed by the VRC.

MARV, a filovirus in the same family as Ebola virus, causes a rapidly progressive febrile illness that leads to shock and death in a large proportion of infected individuals. Many scientists think that MARV disease outbreaks in humans begin by when the virus makes the jump from its primary animal host, which is likely to be certain chronically infected bats in sub-Saharan Africa. The symptoms of MARV disease are akin to those seen with Ebola virus disease and can include fever, headache, chills, rash, abdominal pain, vomiting, and diarrhea. As the disease progresses, patients may suffer from multiple organ dysfunction, delirium, and significant bleeding from the gastrointestinal tract or other sites that may result in death. No approved vaccines or specific therapies are available for MARV disease, aside from supportive care. While some experimental vaccines have previously been tested, none have proven to be both highly effective and to provide durable protection. In areas of Africa where a vaccine for Marburg is most needed, a single-dose vaccine that could protect recipients over a long period of time would be a crucial part of quelling outbreaks.

In this study, 40 healthy adult volunteers were enrolled at the Walter Reed Army Institute of Research Clinical Trials Center in Silver Spring, Maryland. They received a single dose of either a low dose of the vaccine (1x1010 particle units) or a higher dose (1x1011 particle units). For safety, the volunteers were enrolled in a dose-escalation plan. Three participants received the lower dose. Then, when they did not exhibit severe adverse reactions after the first seven days, the trial proceeded to enroll the remaining 17 volunteers. The same procedure was also used for the higher dose group. Volunteers were monitored for adverse reactions to the investigational vaccine and evaluated at regular intervals for 48 weeks to track their immune responses.

The trial’s safety results were encouraging: There were no serious adverse events, and the experimental vaccine was well-tolerated. One participant in the higher dose group developed a fever following vaccination, but it resolved by the following day. In addition, the investigational vaccine appeared to induce strong, long-lasting immunity to the MARV glycoprotein: 95% of participants in the trial exhibited a robust antibody response after vaccination, and 70% maintained that response for more than 48 weeks.

Plans are in place to conduct further trials of the cAd3-Marburg vaccine in Ghana, Kenya, Uganda, and the United States. If additional data supports the promising results seen in the Phase 1 trial, the cAd3-Marburg virus vaccine could someday be used in emergency responses to MARV outbreaks.

Article​

M Hamer et al. Safety, tolerability, and immunogenicity of the Marburg chimpanzee adenovirus vector vaccine (cAd3-Marburg) in healthy adults: a phase 1, open-label, dose-escalation trial. The Lancet DOI: 10.1016/S0140-6736(22)02400-X (2023).

Who​

Lesia Dropulic, M.D., chief of the Clinical Trials Program at NIAID’s Vaccine Research Center, is available for comment.

Contact​

To schedule interviews, please contact Elizabeth Deatrick, (301) 402-1663, [email protected].

NIAID conducts and supports research—at NIH, throughout the United States, and worldwide—to study the causes of infectious and immune-mediated diseases, and to develop better means of preventing, diagnosing and treating these illnesses. News releases, fact sheets and other NIAID-related materials are available on the NIAID website.

About the National Institutes of Health (NIH): NIH, the nation's medical research agency, includes 27 Institutes and Centers and is a component of the U.S. Department of Health and Human Services. NIH is the primary federal agency conducting and supporting basic, clinical, and translational medical research, and is investigating the causes, treatments, and cures for both common and rare diseases. For more information about NIH and its programs, visit www.nih.gov.
 
Surprised he won with the amount of drag his balls would produce hanging out like they were.
 
Can someone please tell my why we are, illegally, in Syria. We fucking invaded a country and not a peep from the rest of the world. How many people have we killed and why doesn't the media cover this shit.

We have been doing tit-for-tat their since 2011. So far eleven are confirmed dead in this airstrike, but toll is expected to be higher.
 

Wow, wonder had it been the other way around? Would the other team be banned from every playing in NCAA again?
 
You know, I don’t think people on the left are thinking this through. Our local Christian schools are busting at the seams because of the woke agendas in public schools. And a large number are going the homeschool route. They did surveys and it turns out that even conservative/moderate non-Christians are cool with their kids getting a Christian education as opposed to learning about trans “issues” and seeing other kids pee in litter boxes.

This means something VERY significant to those of us in the Christian crowd: out of this chaos is an opportunity to teach children at a formidable age about Christ, and with the parents consent and tuition fees added to thier yearly budget. Why? Because it is seen by the parents as a TON safer than trans men crotch dancing on their children with dildos as gifts. Those children have a chance to not only know Christ for the rest of their lives in a saving way but also lead their parents to belief. All while receiving a better education than government funded schools have provided for a good while.

Is it winning? No because society is still degrading morally. But any time a child can be taught with genuine love and care it is a VERY good thing.
 
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