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Show yer Peacemakers, folks!

You can get cylinders in 45acp. They use half moon clips to hold the 45acp by the extractor groove.
Reloading could be a bit aggravating with an SAA style handgun as you'd need to pop the cylinder out if using full-moon, half-moon or 1/3-moon clips.

Keith

ETA: Some manufacturers offered .45ACP cylinders where the cartridge headspaced on the case mouth.