I use a Bushnell Elite Tactical Mil/Mil 6-24X. Yes the dots can cause a problem on pups, and/ or any of them outside 300 yards. Just like any other target, I dial elevation and hold wind. I have a range finder with me at all times but sometimes there isn't enough of a vertical object for the laser to bounce off of, and I resort to milling the prarie dogs.
At home, my elevation is 600' above sea level with a DA range of -500' to +3000'. Where I shoot prarie dogs, in the Texas panhandle, the elevation is 4500' above sea level with a DA range of 4200' to 8000'. By having a Mil/ Mil scope I can input the environmentals and have the correct trajectory for my conditions. This is even with a fast .22-250. I learned the hard way that inputting DA and temp is very important.