Re: pickles without HFCS?
<div class="ubbcode-block"><div class="ubbcode-header">Originally Posted By: tullius</div><div class="ubbcode-body">Read
this article, it's worded as carefully as a news rag can be. Note Havel's (scientist) comments on Lustig's (pediatrician) hypothesis.
Lustig hasn't "found anything", in a study, to refute. He doesn't do lab work. Havel does, however.
This study he co-authored with Stanhope is interesting. Note carefully the parameters of the study.
Here's
another look at HFCS from the American Journal of Clinical Nutrition that's readily available and not behind a paywall. The overwhelming majority of scientific studies agree with this.
The first law of thermodynamics has not been reinterpreted. There is no published study that proves otherwise. </div></div>
Well, if it's of any value to the discussion Havel went on to do the tests he complained about in that 2006 article, and was well into the research by the time that infamous Youtube video started circulating. Being that they're both working in the same lab I'm guessing each was pretty well aware of what the other was doing.
His results were pretty conclusive in the lab;
Teff, Karen L. Joanne Grudziak, Raymond R. Townsend, Tamara N. Dunn, Sean H. Adams, Nancy L. Keim, Bethany P. Cummings, Kimber L. Stanhope, and Peter J. Havel. Endocrine and metabolic effects of consuming fructose- and glucose-sweetened beverages with meals in obese men and women: Influence of insulin resistance on plasma triglyceride responses. J. Clin. Endocrinol. Metab., 94: 1562-1569, 2009.
http://www.ncbi.nlm.nih.gov/pubmed/19208729
Stanhope, Kimber L., Nancy L. Keim, Steven C. Griffen, Andrew A. Bremer, James L. Graham, Bonnie Hatcher, Chad Cox, John P. McGahan, Anthony Seibert, Ronald M. Krauss Sally Chiu, Ernst J. Schaefer, Masumi Ai, Seiko Otokozawa, Katsuyuki Nakajima, Takamitsu Nakano, Carine Beysen, Jean Marc Schwarz, Marc K. Hellerstein, Lars Berglund, and Peter J. Havel. Effects of consuming fructose- or glucose-sweetened beverages for 10 weeks on lipids, insulin sensitivity, and adiposity. J. Clin. Invest. 119: 1322-1344, 2009.
http://www.jci.org/articles/view/37385
Pertinent conclusion of that research:
Studies in animals have documented that, compared with glucose, dietary fructose induces dyslipidemia and insulin resistance. To assess the relative effects of these dietary sugars during sustained consumption in humans, overweight and obese subjects consumed glucose- or fructose-sweetened beverages providing 25% of energy requirements for 10 weeks. Although both groups exhibited similar weight gain during the intervention, visceral adipose volume was significantly increased only in subjects consuming fructose. Fasting plasma triglyceride concentrations increased by approximately 10% during 10 weeks of glucose consumption but not after fructose consumption. In contrast, hepatic de novo lipogenesis (DNL) and the 23-hour postprandial triglyceride AUC were increased specifically during fructose consumption. Similarly, markers of altered lipid metabolism and lipoprotein remodeling, including fasting apoB, LDL, small dense LDL, oxidized LDL, and postprandial concentrations of remnant-like particle–triglyceride and –cholesterol significantly increased during fructose but not glucose consumption. In addition, fasting plasma glucose and insulin levels increased and insulin sensitivity decreased in subjects consuming fructose but not in those consuming glucose. These data suggest that dietary fructose specifically increases DNL, promotes dyslipidemia, decreases insulin sensitivity, and increases visceral adiposity in overweight/obese adults.
That is interesting. It sounds like according to Havel consumption of fructose and not glucose promotes all the negative effects. I think Lustig attempts to expand upon that and differentiate fructose chained to glucose and fiber from fruits(not fruit juice), but I'm not certain there's research confirming any of that.
